Caspase-2–selective tools

The scientific case

  • Distinct biology you can’t decipher see with pan-caspase tools.

    Caspase-2 (Casp2) regulates synaptic function (AMPA-receptor trafficking), and dementia-related pathogenic signals (tau cleavage, amyloid-beta signaling), neuronal survival under stress, genome-integrity checkpoints (extra-centrosome surveillance), metabolic/ER-stress responses, and retinal ganglion cell death. If you use non-selective inhibitors or generic substrates, you blur Casp2 with Casp3/7/8 and lose mechanistic signal.

    Reserve Your Batch

  • Actionable across multiple fields

    Neuroscience (AD/FTD/tauopathies, memory), ophthalmology (RGC protection), oncology (chromosomal instability pathways), hepatology/metabolism (lipotoxic stress, NASH), and ischemia models.

    Reserve Your Batch

The practical case

  • Selectivity = clarity

    Our reagents are engineered to maximize discrimination versus executioner caspases (3/7) and inflammatory caspases (1/4/5). That means cleaner readouts, fewer false leads, and data you can defend in manuscripts, diligence, and IND-enabling packages.

    Reserve Your Batch

  • Faster decisions

    Pair our fluorogenic Casp2-selective AMC substrates with our Casp2 inhibitors to run rapid MoA confirmation, SAR ranking, and target-engagement/competition assays on a plate reader—no special hardware required.

    Reserve Your Batch

  • Translationally minded

    The same chemistry principles underlie our activity-based probe and our therapeutic inhibitor series, so your tool data maps naturally to drug discovery hypotheses.

    Reserve Your Batch

What we offer

    • Use cases: target validation, pathway dissection, rescue experiments, chemical genetics, lead profiling (tool-versus-therapeutic benchmarking).

    • What you get:

      • High-purity small molecules (CoA with purity and identity).

      • Recombinant caspase panel selectivity (datasheet), IC₅₀ or kinact/KI where applicable.

      • DMSO-friendly stocks; buffer recommendations and ready-to-run protocols.

      • Optional bundle with matched substrate/probe for immediate TE (target engagement).

      • Inactive control

    • Why AMC? Real-time kinetic readouts (Ex/Em ≈ 350/440 nm) on any standard plate reader; ideal for HTS, enzyme kinetics (KM, kcat), and cell/lysate assays.

    • What you get:

      • Optimized tetrapeptide recognition structure (peptidomimetic derivated from pentapeptide) for Casp2 selectivity (reduces cross-talk with Casp3/7).

      • Validated linear range, guidance for screening, and interference controls.

      • Protocols/advice for: purified enzyme, cell lysate, and live-cell compatible workflows.

All products are for Research Use Only (RUO). Not for diagnostic or clinical use.

What makes IPcure different

  • Designed for Casp2, not “pan-caspase with hopes.” You get an order-of-magnitude selectivity window vs. major off-targets (see datasheets).

  • Every shipment includes: CoA, QC traces, panel data summary, step-by-step protocols, and troubleshooting notes.

  • We provide lot-to-lot comparability, recommended controls (positive/negative, pan-caspase benchmarking).

  • Tools validated in vitro, in cellulo, and in vivo (where applicable) help you move from mechanism to models to partnering conversations without swapping targets or assays.

Buying options

Casp2i™ 

(small vial: frozen solution at 10mM or lyophilized powder 1-5 mg) + protocols + control recommendations.

Casp2ci™

inactive control inhibitor (small vial: frozen solution at 10mM or lyophilized powder 1-5 mg) + protocols + control recommendations.

Casp2-AMC™

(small vial: frozen solution or lyophilized powder 1-5 mg)

Starter Kit

1× Casp2i™ (small vial) + 1× Casp2-AMC™ + protocols + control recommendations.

Custom & bulk

Quote on request (POs, academic pricing, framework agreements available).

Performance, QC & support

  • ≥95% (HPLC) with full MS; water and residual solvent specs.

  • Recombinant caspase panel and orthogonal protease screen (summary on datasheet).

  • DMSO stock; validated buffers (pH/ionic strength), detergent tolerances, and recommended cell media conditions.

  • CoA, SDS, protocols, reference list.

  • Scientist-to-scientist help in <48 h (method setup, data interpretation, custom requests).

How to get started

Interested in working together? Fill out some info and we will be in touch shortly! We can't wait to hear from you!