Caspase-2–selective tools

How to get started

What we offer

    • Use cases: target validation, pathway dissection, rescue experiments, chemical genetics, lead profiling (tool-versus-therapeutic benchmarking).

    • What you get:

      • High-purity small molecules (CoA with purity and identity).

      • Recombinant caspase panel selectivity (datasheet), IC₅₀ or kinact/KI where applicable.

      • DMSO-friendly stocks; buffer recommendations and ready-to-run protocols.

      • Optional bundle with matched substrate/probe for immediate TE (target engagement).

      • Inactive control

    • Why AMC? Real-time kinetic readouts (Ex/Em ≈ 350/440 nm) on any standard plate reader; ideal for HTS, enzyme kinetics (KM, kcat), and cell/lysate assays.

    • What you get:

      • Optimized tetrapeptide recognition structure (peptidomimetic derivated from pentapeptide) for Casp2 selectivity (reduces cross-talk with Casp3/7).

      • Validated linear range, guidance for screening, and interference controls.

      • Protocols/advice for: purified enzyme, cell lysate, and live-cell compatible workflows.

All products are for Research Use Only (RUO). Not for diagnostic or clinical use.

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Buying options

Casp2i™ 

(small vial: frozen solution at 10mM or lyophilized powder 1-5 mg) + protocols + control recommendations.

Casp2ci™

inactive control inhibitor (small vial: frozen solution at 10mM or lyophilized powder 1-5 mg) + protocols + control recommendations.

Casp2Sense™

Fluorogenic substrate AMC-based (small vial: frozen solution or lyophilized powder 1-5 mg)

Starter Kit

1× Casp2i™ (small vial) + 1× Casp2Sense™ + protocols + control recommendations.

The practical case

  • Selectivity = clarity

    Our reagents are engineered to maximize discrimination versus executioner caspases (3/7) and inflammatory caspases (1/4/5). That means cleaner readouts, fewer false leads, and data you can defend in manuscripts, diligence, and IND-enabling packages.

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  • Faster decisions

    Pair our fluorogenic Casp2-selective AMC substrates with our Casp2 inhibitors to run rapid MoA confirmation, SAR ranking, and target-engagement/competition assays on a plate reader—no special hardware required.

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  • Translationally minded

    The same chemistry principles underlie our activity-based probe and our therapeutic inhibitor series, so your tool data maps naturally to drug discovery hypotheses.

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The scientific case

  • Distinct biology you can’t decipher with pan-caspase tools.

    Caspase-2 (Casp2) regulates synaptic function (AMPA-receptor trafficking), and dementia-related pathogenic signals (tau cleavage, amyloid-beta signaling), neuronal survival under stress, genome-integrity checkpoints (extra-centrosome surveillance), metabolic/ER-stress responses, and retinal ganglion cell death. If you use non-selective inhibitors or generic substrates, you blur Casp2 with Casp3/7/8 and lose mechanistic signal.

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  • Actionable across multiple fields

    Neuroscience (AD/FTD/tauopathies, memory), ophthalmology (RGC protection), oncology (chromosomal instability pathways), hepatology/metabolism (lipotoxic stress, NASH), and ischemia models.

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What makes IPcure different

  • Designed for Casp2, not “pan-caspase with hopes.” You get an order-of-magnitude selectivity window vs. major off-targets (see datasheets).

  • Every shipment includes: CoA, QC traces, panel data summary, step-by-step protocols, and troubleshooting notes.

  • We provide lot-to-lot comparability, recommended controls (positive/negative, pan-caspase benchmarking).

  • Tools validated in vitro, in cellulo, and in vivo (where applicable) help you move from mechanism to models to partnering conversations without swapping targets or assays.

Performance, QC & support

Close-up of laboratory equipment including test tubes with color-coded caps, and robotic machinery working on the test tubes in a medical or scientific laboratory.

  • ≥95% (HPLC) with full MS; water and residual solvent specs.

  • Recombinant caspase panel and orthogonal protease screen (summary on datasheet).

  • DMSO stock; validated buffers (pH/ionic strength), detergent tolerances, and recommended cell media conditions.

  • CoA, SDS, protocols, reference list.

  • Scientist-to-scientist help in <48 h (method setup, data interpretation, custom requests).

How to get started

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